Abstract for presentation at 38th Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine 2008

F18 FDG PET/CT in a Malignant Peripheral Primitive Neuroectodermal Tumour (PNET) Arising from the Kidney

  • Mrs Justine Trpezanovski, Department of Nuclear Medicine, The Children's Hospital , Westmead, Australia
  • Dr Kevin London, Department of Nuclear Medicine, The Children's Hospital , Westmead, Australia
  • Dr Susan Arbuckle, Department of Histopathology, The Children's Hospital , Westmead, Australia
  • Prof Robert Howman-Giles, Department of Nuclear Medicine, The Children's Hospital , Westmead and Discipline of Imaging, University of Sydney, Australia

    • Malignant Primitive Neuroectodermal Tumours (PNET) are classified as a member of the Ewings sarcoma family and most commonly arise in soft tissues. The application of F18FDG PET/CT in Ewings sarcoma of bone and other soft tissue sarcomas is well reported for assessment of metastases, response to therapy and recurrence of disease. There is however little data regarding PNET specifically. This is a case of a PNET arising from a kidney in a paediatric patient. The application of F18FDG PET/CT in this case is described.
    Case Report: A 14 year old female presented with right flank pain. CT scan revealed a large renal mass arising from the lower region of the right kidney. There was also calcification within the mass. PET/CT scans showed avid uptake of FDG (SUV max 5.4) into the right renal tumour. There was heterogeneous uptake consistent with areas of necrosis within the tumour and no FDG avid metastases were detected. CT confirmed no pulmonary or abdominal metastases. Surgical resection of the tumour and right kidney was performed. Histopathology revealed a PNET. There was no evidence of nodal metastases. Post surgery F18FDG PET/CT scans have revealed no residual or metastatic disease.
    Conclusion: PNET in children are rare and even more so arising from the kidney. FDG PET/CT was shown to be avid in this tumour and potentially can be used in follow up to determine recurrence and metastases.

    Conference Organiser - ICMS Pty Ltd